Variation in IL6 in RA was reported when measured every 3 h between 07:30–22:3015 and when measured over 24 h in five newly-diagnosed patients a peak occurred at 07:00.10 In two studies of low dose glucocorticoid (prednisolone <7.5 mg equivalent) given at 02:00 compared with 07:30, IL6 and symptoms were both improved at 08.00.16, 17 Thus, it is possible that variation in IL6 is related to variation in symptoms. Here, IL6 is linked to rheumatoid arthritis.