There was an overall association of TLR2 T597C with meningeal disease (OR = 1.51 [95% C.I. 1.12–2.03] P = 0.006) but this was not significant for meningeal disease caused by non-Beijing isolates (control vs. TBM non-Beijing OR = 1.25, [95% C.I. 0.86–1.82], P = 0.243). Here, TLR2 is linked to meningitis.