Strikingly, following infection with S. mansoni, CAT2−/− mice developed granulomas that were 3- to 4-times larger than WT and hepatic fibrosis (a feature of severe disease) was significantly exacerbated in chronically infected mice [26],[27],[28],[29], indicating a general worsening of Th2-associated pathologies in the absence of CAT2. Here, SLC7A2 is linked to Hepatic fibrosis.