ATRX and alpha thalassemia-X-linked intellectual disability syndrome: Notably, recent evidence indicates that helicases of the SWI/SNF2 family of chromatin remodeling proteins such as ATRX (alpha thalassemia/mental retardation syndrome X-linked) and the lymphoid specific helicase (LSH), also known as helicase lymphoid specific (Hells) bind to pericentric heterochromatin regions in mouse somatic cell lines where they also play an essential role in DNA methylation [26-31].