Three different mouse models (transgenic mice with a yeast artificial chromosome that includes the human DYRK1A gene, transgenic mice overexpressing the cDNA of rat Dyrk1a, and transgenic mice with one extra copy of the human DYRK1A gene in a bacterial artificial chromosome) were generated and found to exhibit neurodevelopmental delays and impairment in learning tasks [11-13]. Here, DYRK1A is linked to Neurodevelopmental delay.