COMT and glomerulosclerosis: In addition, administration of nitecapone, an inhibitor of dopamine metabolizing enzyme catechol-O-methyltransferase (COMT; EC 2.1.1.6), has been found to effectively abolish glomerular hypertension and reduce progression to glomerulosclerosis by inhibiting Na-K-ATPase in a dopamine dependent fashion [10,11].