These non-human mammals generally showed the conserved nucleotides present in the human wild type, not the mutations to Runx2 concentrated in the DNA binding domain among human CCD patients (see Tables 1 and 2 in [19]), except for a sequence of Canis. This specimen (GenBank XM_532158) [39] exhibits many changes to its Runx2 sequence, including a mutation commonly present among genetically documented human patients with CCD [19]: instead of the 'CGG' codon for arginine (R) at codon 225, they exhibit a 'CAG' codon for glutamine (Q). This evidence concerns the gene RUNX2 and cleidocranial dysplasia 1.