Annexin 3 level was increased during episodes of migraine [14]; microtubule-associated protein 1B was altered 7 days after chronic constriction injury (CCI) [15]; synaptoporin, a major synaptic vesicle protein in Adelta- and C-fibers and co-localized with calcitonin gene-related peptide (CGRP) in sensory primary afferent neurons, increased after peripheral nerve injury [16]. The gene discussed is SYNPR; the disease is migraine disorder.