We Analyzed the factors by single factor logistic regression model, and found that 8 factors are likely related to hypercortisolism of adrenocortical diseases including abdominal mass, decrease in bone content or fracture, blood cortisol level (4PM), blood ACTH level (8AM), tumor size, FHIT, Ki-67, PCNA. Here, POMC is linked to adrenal gland hyperfunction.