This indicates that there are statistically significant differences among the diagnosis of hypercortisolism of various adrenocortical diseases using differential gene expression levels of FHIT, Ki-67, PCNA and a few factors that include abdominal mass, decrease in bone content or fracture, blood cortisol level (4PM), blood ACTH level (8AM), tumor size, and blood cortisol level (4PM, P< 0.10, the others P < 0.05) (table 11). Here, POMC is linked to neoplasm.