We chose two genes known to be regulated by E2 (BCL2 and TFF1/pS2), and several others with interesting expression patterns and potential relevance to cell proliferation and cancer, including RGS16 (Regulator of G protein signaling 16), RAP1GAP (Rap1 GTPase activating protein 1), CCNG2 (Cyclin G2) and EPHB3 (Ephrin type-B receptor 3 precursor). The gene discussed is CCNG2; the disease is cancer.