APP tg B6SJL mice immune hyporesponsiveness to Aβ suggesting that an Aβ-specific impaired adaptive immune response may contribute to neuropathology [39]; increase of autoantibodies to Aβ in AD patients suggests that a humoral immune response to Aβ may promote neuronal degeneration, a process with implications for future vaccine-based therapies of AD [40]. This evidence concerns the gene APP and Alzheimer disease.