Increased CSF tau is also seen in other CNS disorders with neuronal loss (degenerative, inflammatory, vascular, tumours), with highest CSF tau concentrations in Creutzfeldt-Jakob disease (CJD) and brain infarcts, the former showing a dissociation between tTau and pTau [162], while AD and AD+CVD display a similar neurochemical phenotype with increased tau and diminished Aβ-42, with some overlap between AD and VaD, the latter showing a decrease of CSF Aβ-38/40 [158, 163], as well as in plasma [164]. This evidence concerns the gene MAPT and central nervous system disorder.