THBS1 and neoplasm: These findings clinically confirmed that low-dose CPT-11 inhibits angiogenesis, in part, by upregulating TSP-1 in tumour endothelial (Bocci et al, 2003), or tumour and tumour-associated stromal cells (Hamano et al, 2004), promoting endothelial cell apoptosis (de Castro Junior et al, 2006) and suppressing the mobilisation of circulating endothelial progenitors (Shaked et al, 2005).