The indirect effects were mainly mediated through proteins involved in lipid metabolism, such as ADFP [31], phospholipid transfer protein [32], and angiopoietin-like protein 4 [33], where the strongest one was the indirect effect of PPARD mediated by ADFP. A major role of the PPAR proteins in the development of aggressive breast cancers is, therefore, probably to deregulate lipid metabolism through interactions with these proteins. This evidence concerns the gene ANGPTL4 and breast cancer.