CSF3 and Decreased total neutrophil count: Previously, the dose limiting toxicity of many chemotherapeutic agents was hypersensitivity and neutropenia, but since the former can now be treated with antihistamines or steroids and the latter with granulocyte colony-stimulating factor [45], peripheral neuropathy is the de facto toxicity that limits the administration of many commonly used anti-neoplastic agents [11-14].