The chemokine receptors CXCR4, CXCR3 and CCR5 were all increased on day 8 Tck cells to varying extents, but in the RA synovial tissue examined here only CXCR3 was found to be upregulated on the RA synovial T cells. The gene discussed is CXCR3; the disease is rheumatoid arthritis.