In the present study, however, we did not find a significant inhibitory role for either anti-LFA-1 antibody or anti-VLA-4 antibody during CD44v4-mediated breast cancer cell migration across TNF-α pre-activated HUVEC monolayers (Fig. 1), strongly arguing for a minor role of leukocyte-specific integrins in breast cancer cell metastasis. This evidence concerns the gene TNF and breast cancer.