In that study, LRP6 was identified through a genome-wide antisense RNA screening approach to be important for intoxication of human M2182 prostate carcinoma cells by PA and FP59, a recombinant toxin comprised of the N-terminal portion of LF fused to Pseudomonas exotoxin A. Consistently, siRNA-mediated knockdown of LRP6 levels in these cells reduced their toxin sensitivity by several orders of magnitude, an effect that was partially overcome by expression of an siRNA-resistant form of LRP6. The gene discussed is LRP6; the disease is prostate carcinoma.