KLK3 and prostate neoplasm: For example, of the 559 genes in the Chen androgen signature (448 of which were represented in at least three prostate tumor datasets), 29 were correlated (p<0.05) with KLK3 in at least three out of the four prostate tumor datasets; by chance, nine were expected, and so the amount of actual overlap was quite significant (p = 1.2E-08).