Taubert's groupreported that glucose and insulin stimulated NO release was impaired in the presence of hyperglycemia lastingbeyond 2 hours, and that acute hyperglycemia did not increase NO release afterprolonged exposure to hyperglycemia, leading them to suggest that enhancedsuperoxide generation in chronic hyperglycemia could be responsible foraccelerated NO degradation. This evidence concerns the gene INS and Hyperglycemia.