NFKB1 and Hyperglycemia: The interaction between RAGE and its ligands, advanced glycation end products (AGEs) such as lipids and nucleicacids resulting from oxidative stress and hyperglycemia [68], activates NFκB, which leads to transcription of proinflammatory factors [69].Even if their relevance for obesity is still unclear, AGEs were shown toaccumulate in pathological conditions such as diabetes or under particularlife-style habits such as unhealthy diet consumption [70].