Indeed, while some reports described noeffect on body weight [46, 64, 66], other authors described an increased bodyweight [41] or, in contrast, a protection against diet-induced obesity [47].Similarly, adiposity and food intake were either reported to be unchanged,increased, or decreased in TLR4-deficient animals [41, 46, 47, 64]. This evidence concerns the gene TLR4 and obesity due to melanocortin 4 receptor deficiency.