Therefore TLR4, being expressed in most tissues ofthe body—including theinsulin-sensitive ones such as adipose tissue (cf. Section 1.4.2), muscle, andliver [47]—and due to itsactivation by lipopolysaccharide and saturated fatty acids, which are bothinducers of insulin-resistance, appears to be an essential mediator of bodilyinsulin-resistance. This evidence concerns the gene TLR4 and Insulin resistance.