The average cumulative risks of breast cancer in BRCA2 mutation carriers by the age of 70 years were estimated to be lower, 39% for women born before 1920 (6.3 and 93% at the 5th and 95th percentiles, respectively) rising to 51% for those born after 1950 (9.8 and 98.7% at the 5th and 95th percentiles, respectively). The gene discussed is BRCA2; the disease is breast carcinoma.