CAV1 and neoplasm: Moreover, caveolin-1 expression, which has been demonstrated in normal and benign ovarian tumours, has been shown to recede in high-grade ovarian carcinomas, and forced expression of caveolin-1 in ovarian cancer cells resulted in loss of cell survival, consistent with the tumour-suppressing role of caveolin-1 described for other cancers (Wiechen et al, 2001).