It is noteworthy that lymph node metastasis and lymphatic invasion are correlated with CD133 expression, as a recent study demonstrated that a melanoma cell line highly enriched with CD133-expressing cells concomitantly expresses lymphoangiogenic markers, vascular endothelial growth factor receptor (VEGFR)-3 and lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 (Monzani et al, 2007). This evidence concerns the gene LYVE1 and melanoma.