Overall, the effect of a shift from anti- to proangiogenic VEGF expression predominance in CRC cell lines was due to a combination of reduced VEGFxxxb expression and increased VEGFxxx expression, resulting in a shift from 82±10% VEGFxxxb in adenoma cells to between 5.7±0.3 and 53±5.8% in the carcinoma cell lines (P<0.0001, one-way ANOVA, Figure 6C). Here, VEGFA is linked to carcinoma.