To determine if there was a direct correlation between EDD expression and cisplatin resistance, we compared the relative cisplatin resistance (IC50) of six ovarian cancer cell lines of differing histological subtypes to their levels of EDD protein as determined by western blotting, as compared to the immortalised ovarian surface epithelial cell line HOSE 17.1 (Table 4). This evidence concerns the gene UBR5 and ovarian carcinoma.