Although somatic mutations in the EDD gene have been reported in gastric and colorectal tumours (Mori et al, 2002) and in mammary ductal carcinoma (Fuja et al, 2004), we have not identified any deleterious EDD mutations in a number of ovarian cancer cell lines (Clancy et al, 2003), and therefore, we predict that EDD mutation would be a very rare event in ovarian cancer and hence assume that EDD is functional in ovarian cancer. Here, UBR5 is linked to colorectal neoplasm.