Similar to VEGF, we did not find any association between cell cycle markers and EDD expression in this cohort, including the tumour suppressor p53, which is a key mediator of cellular responses to DNA damage through modulation of cell cycle regulation, DNA repair and activation of pathways leading to apoptosis and is implicated in the development of cisplatin-resistance in ovarian cancer (Kigawa et al, 2001). This evidence concerns the gene VEGFA and ovarian cancer.