A common phenomenon of tumour formation is the amplification of proto-oncogenes such as HER2 (Parkes et al, 1990), EGFR (Reissmann et al, 1999), CCND1 (Szepetowski et al, 1992; Reissmann et al, 1999), and c-MET (Rege-Cambrin et al, 1992), which provide a selective advantage for tumour cell growth and survival through overexpression. This evidence concerns the gene CCND1 and neoplasm.