The top three nodes that act as highly connected hubs are: BRCA1, MYC, and BLM for LASH; BRCA1, MYC and c-JUN for withanone; BRCA1, JAK2 and TERT for withaferin A. Additionally, the cellular networks of the LASH showed greater similarity to withanone (i-Factor) compared to that of withaferin A, and that these interwoven pathways correlated with selectivity in tumor action of the former two agents. The gene discussed is JAK2; the disease is neoplasm.