Hypermethylation of MAL has, by quantitative methylation-specific polymerase chain reaction (MSP), previously been shown by others to be present only in a small fraction (6%, 2/34) of colon carcinomas [31], even though the expression of MAL was reported to be reduced/lost in the majority of colorectal tumours [11,17,31]. Here, MAL is linked to colorectal neoplasm.