FTO and obesity due to melanocortin 4 receptor deficiency: Although two genes for obesity have already been reported from the outcome of genome wide association (GWA) studies, the role of INSIG2 gene[30] has proven to be controversial due to three subsequent technical comments to Science[31], [32], [33] that disagreed with this observation, while the identification of the second gene, FTO [NM_001080432][34], was made indirectly as a consequence of T2D GWA studies[35], [36].