Two SNPs (rs1126772 and rs9138) in the 3′ UTR in the SPP1 gene were associated with high levels of SPP1 and elevated risk of developing autoimmune/lymphoproliferative syndrome (ALPS), a disorder which leads to an autoimmune pattern similar to lupus prone strains of mice [16]. This evidence concerns the gene SPP1 and systemic lupus erythematosus.