ERBB2 and breast carcinoma: Trastuzumab (HerceptinTM) a humanised anti-HER2 antibody has recently been approved for the adjuvant treatment of HER2-overexpressing (3+ IHC) or FISH-positive primary breast cancers based on a highly significant reduction in the risk of recurrence of 52% in node-positive HER2-positive primary breast cancer (Romond et al, 2005).