To date, at least 14 loci from GLC1A to GLC1N have been linked to POAG, and three genes have been identified, the myocilin (MYOC) gene [4,5], the optineurin (OPTN) gene [6], and the WD repeat domain 36 (WDR36) gene [7]. The gene discussed is OPTN; the disease is open-angle glaucoma.