CEP290 and Leber congenital amaurosis: Genes implicated in LCA causation include retinal guanylate cyclase (GUCY2D) on chromosome 17p13.1 (LCA1), RPE65 on chromosome 1p31 (LCA2), RDH12 on chromosome 14q23.3 (which may account for the LCA3 locus, though this remains to be clarified), AIPL1 on chromosome 17p13.1 (LCA4), RPGRIP1 on chromosome 14q11 (LCA6), CRX on chromosome 19q13.3 (LCA7), CRB1 on chromosome 1q31.3 (LCA8), CEP290 on chromosome 12q21.3 (LCA10), and IMPDH1 on chromosome 7q32.1 (LCA11) [2].