Linkage analysis mapped the disease gene to 2q33–35, and a missense mutation (181G→C) in CRYGD was identified in this family, resulting in the substitution of Gly61Cys (P.G61C) in CRYGD. Analysis of the wild-type and mutant proteins suggested that increased stability, complexity, and decreased hydrophilicity of the mutant protein may be the cause of coralliform congenital cataracts. The gene discussed is CRYGD; the disease is early-onset non-syndromic cataract.