Mutations in the CRB1 (Crumbs homolog 1) gene have been found in patients with RP12, with and without PPRPE, RP patients who developed Coats-like exudative vasculopathy, and in 10%–13% of patients with Leber congenital amarousis (LCA). Here, CRB1 is linked to retinitis pigmentosa 1.