CD4 and neoplasm: This perception is based on the following: (i) several melanoma-specific antigens have been identified; (ii) melanoma antigen-specific CD4+ and CD8+ T lymphocytes are increased in melanoma patients and have anti-tumor activity; (iii) immune-enhancing agents can cure mice of established melanomas; and (iv) spontaneous melanoma regressions in humans with the simultaneous onset of vitiligo have been reported [1,2].