Furthermore, there is potential for cross-talk between IKK/NF-κB and other major signal pathways, such as the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), JAK/STAT (Janus kinase/signal transducer and transcription factor), and p53 pathways, which have been implicated in significantly affecting the cancer phenotype, including proliferation, apoptosis, angiogenesis and tumorigenesis [1,4,27-30]. The gene discussed is NFKB1; the disease is cancer.