These include the demonstration of alterations and the biological and clinical significance of NF-κB activation and of multiple NF-κB-regulated genes and cytokines expressed in HNSCC tumor specimens and serum [18,32,33,42,80,81], and the demonstration of an inverse relationship between NF-κB and p53 nuclear localization and associated protein expression in tumors [35]. The gene discussed is NFKB1; the disease is head and neck squamous cell carcinoma.