These known NF-κB target genes, such as IL6, IL8, BIRC2 (clAP-1), ICAM1, YAP1, CDKN1A (p21), CSF2, CCDN1, IL1A, IL1B, and so on, include many that have been independently confirmed to be differentially expressed and pathologically implicated in HNSCC and other cancers [6-8,39,44,49-52]. This evidence concerns the gene CDKN1A and head and neck squamous cell carcinoma.