Interestingly, the overall ratio of approximately 60% of differentially expressed genes in human UM-SCC cells is remarkably consistent with the approximate percentage of genes in murine squamous cell carcinoma restored to expression levels seen in non-malignant cells of syngeneic origin by inhibition of NF-κB using an inducible mutant IκBα [13]. This evidence concerns the gene NFKBIA and squamous cell carcinoma.