NFKB1 and cancer: Using Ingenuity Pathway Analysis, the NF-κB targets were reverse-engineered into annotated signature networks and pathways, revealing relationships broadly altered in cancer lines (activated proinflammatory and down-regulated Wnt/β-catenin and transforming growth factor-β pathways), or specifically defective in cancer subsets (growth factors, cytokines, integrins, receptors and intermediate kinases).