TP53 and head and neck squamous cell carcinoma: We recently identified specific gene expression signatures in HNSCC cell lines (UM-SCC, University of Michigan Cell Lines Series of Head and Neck Squamous Cell Carcinoma), which were associated with differing p53 status and NF-κB regulatory activity, subsets previously associated with differences in prognosis, response to chemoradiation or metastatic phenotypes [14].