MBL2 and hyperinsulinemic hypoglycemia, familial, 4: Furthermore, MBL deficiency does not appear to play a role once polyarthritis has developed, because no associations were found between MBL2 genotype and the laboratory variables or the remaining disease severity related clinical variables, such as PGA, CHAQ score, number of actively involved or affected joints, and number of patients with uveitis or remission.