GNAS and metabolic syndrome: Notable differences in baseline characteristics by genotype were as follows: ADRA1A Cys347 homozygotes had a lower prevalence of dyslipidemia (Arg/Arg 53%, Arg/Cys 50%, Cys/Cys 40%, P = 0.04) and higher diastolic blood pressure (Arg/Arg 75 ± 10 mmHg Arg/Cys 77 ± 11 mmHg, Cys/Cys 79 ± 11 mmHg, P = 0.02), GNAS 393C homozygotes had a lower hypertension prevalence (T/T 65% T/C 58% C/C 52%, P = 0.05) and systolic BP (139 ± 23 mmHg, 137 ± 21 mmHg, 133 ± 19 mmHg, P = 0.02), and GNB3 825T homozygotes had a higher prevalence of diabetes (C/C 21%, C/T 20%, T/T 40%, P = 0.0002).