As shown with the example colon cancer data, CASP8_03 plus GSTT1_02 was the highest scoring 2-SNP combination overall, while IL1B_01 plus IL1B_03 was the highest-ranking 2-SNP combination using only the Gini Index scoring function, indicating that each function may have strengths in different contexts or datasets. This evidence concerns the gene IL1B and colonic neoplasm.