VEGFC and metastatic malignant neoplasm in the lymph nodes: It is interesting however, that other groups have found a high microvessel density, measured by factor 8 immunohistochemistry, was associated with a high incidence of metastasis (axillary or distant or both) in breast cancer [27] and also that regional lymph node lymph vessel density was positively correlated with lymph node metastasis, VEGF-C expression and a poor prognosis [28,29]