Moreover, coincident with the identification of the scurfy gene as encoding FOXP3 in mice, the human ortholog was cloned and found to be mutated in individuals suffering from the X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome [24], and the X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy (IPEX) syndrome [25], [26]. Here, FOXP3 is linked to immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.