Also, SLE serum induced IFN-α production in healthy PBMCs correlated with the amount of immune complexes in SLE serum (Figure 3c), and the degree of CpG-induced IFN-α production in SLE PBMCs was inversely correlated with the amounts of immune complexes in matched SLE patients (Figure 3d). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.