Among the most highly dysregulated diabetes-associated genes were protein kinase C and vascular cell adhesion molecule in aorta, retinol-binding protein and angiopoietin-like protein in kidney, lipoprotein lipase and apolipoprotein A-IV in liver, vasoactive intestinal peptide receptor and serpin peptidase inhibitor in retina. The gene discussed is LPL; the disease is diabetes mellitus.