CXCL1 and neoplasm: [29], [30] After NF-κB is activated, NF-κB moves to the cell nucleus and controls the expression of numerous genes related to inflammation, tumor development, immune responses and tissue repair. [31], [32] Furthermore, Wood et. al. showed that the human CXCL1 gene has an NF-κB binding site (GGGAATTTCC) in its upstream promoter region, which is essential for IL-1 to induce CXCL1 promoter activity. [33] Therefore, the effects of PDGF on stimulating chemokine expression may depend on NF-κB.