In line with previous studies in animal models of obesity [21], [22], mRNA for c-fms (Figure 5A; Z = 2.72 p = 0.01) as well as F4/80 staining (Figure 5B) were increased in adipose tissue from obese TRAP+ mice indicative of an increase of infiltrating macrophages in adipose tissue. The gene discussed is CSF1R; the disease is obesity due to melanocortin 4 receptor deficiency.