While early autopsies of PWS brains revealed a reduction in the size of the paraventricular nucleus containing fewer oxytocin-preducing neurons and a 30% reduction in GHRH-producing neurons in the nucleus arcuatus of the hypothalamus [36], more recent studies of hypothalami from six adult obese PWS individuals did not confirm a reduction of GHRH-neurons [37]. This evidence concerns the gene OXT and Prader-Willi syndrome.