Chemokines have been proposed to play a majorrole in the activation and recruitment of leukocytes to sites of inflammation.CCL5 is a chemoattractant for multiple leukocyte subtypes (predominantly Tcells) via three known G protein-coupled receptors (GPCRs), CCR1, CCR3, andCCR5 [19] while CCL3 signals towards a similar spectrum of mononuclear cells.CCL3 and CCL5 are produced in the CNS of individuals with severalneuroinflammatory diseases including MS. The gene discussed is CCL3; the disease is glycogen storage disease VI.