Higher ROS levels and SAPK (stress-activated protein kinases) JNK activity were measured in tumour cells that were sensitive to anticancer agents than in those that were drug-resistant, suggesting that ROS-mediated JNK and p38 activation played a key role in the sensitisation to stress signals and to anticancer drugs (Benhar et al, 2001; Davis et al, 2001). The gene discussed is MAPK8; the disease is neoplasm.