AKT1 and neoplasm: The combined treatment with gefitinib and everolimus potentiates antitumour and antiangiogenic effects also in mice bearing GEO and GEO-GR xenografts, in which we observed a cooperative antitumour activity resulting in over 90% tumour growth inhibition on day 56, a dramatic survival prolongation; these effects correlate with a potent inhibition of Akt activation and with a serum reduction of hVEGF but not of mVEGF.